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Homepage > Blog > What is chromosome genetic testing for IVF?
June 17, 2022  |  By nagendra In Blog, IVF Advanced

What is chromosome genetic testing for IVF?

What is chromosome genetic testing for IVF?

In case of opting for IVF, the patient may be offered a test to look at one’s embryos’ chromosomes. Pre-implantation genetic testing for aneuploidy (chromosome abnormalities), known as PGT-A, is meant to choose embryos with the right number of chromosomes.

IVF in Hyderabad cost is reasonable as compared to the world over. IVF in Hyderabad is done expertly.

Also, an embryo may indeed be screened or tested for a specific genetic condition such as spinal muscular atrophy, cystic fibrosis, and also breast cancer. There are several genetic testing options available. 

WHAT IS PGT?

Earlier PGT happened to be known as PGS (pre-implantation genetic screening) or PGD (pre-implantation genetic diagnosis). PGS and PGD are of course two different types of genetic testing. 

PGS (Pre-implantation genetic screening) tests an embryo for its proper number of chromosomes. In case the embryo does not have the proper number of chromosomes, it is referred to as aneuploidy.

PGD (Pre-implantation genetic diagnosis) happened to be another type of genetic screening which does detect the presence of genes for specific diseases.

PGD is now known as PGT-m. The M is for monogenic (or single-gene) disease. 

What is chromosome genetic testing for IVF?

THE PROS OF IVF GENETIC TESTING

  • The patient can identify the best embryos when there are several to choose from. 
    •  The number of eggs a woman has retrieved does vary and can occasionally result in a large number of embryos. The best embryos to transfer can rather be chosen based on their appearance or the rate of growth. Genetic testing can also further help choose a highly competent embryo and also allows for a single embryo transfer while also maintaining a high chance of implantation.
  • Reduces the chances of a genetically abnormal embryo
    • As women tend to age the number of genetically competent embryos gets lowered. This can lead to lower pregnancy rates, more miscarriages, and also an increased risk of having a baby with a chromosomal issue. 
  • Consistent unexplained infertility 
    • Unexplained infertility does occur in approximately 15% of patients trying for a baby. The cause may be identified when a person tests the embryos and testing can aid in finding out the embryo with the highest chance of pregnancy.
  • Avoid passing on a particular genetic condition
    • PGT can be made used to identify the total number of chromosomes and their location referred to as PGT-a (where “a” stands for aneuploidy, or “abnormal-chromosome status”) or even to identify a particular abnormal gene, called PGT-m (where “m” means “monosomy” or “monogenic”). If the person has a genetic condition then the patient does not want to pass on to the child, PGT-m can be made use of to eliminate this sort of genetic problem for the next generation of one’s family.

THE CONS TO IVF GENETIC TESTING

  • When you only have a few embryos

The number of embryos suggested for transfer much depends on the odds of success. 

  • If having young eggs

Eggs collected from women in their twenties and early thirties usually result in high numbers of genetically competent embryos. 

  • Testing may not add any benefit

If the patient reason for undergoing IVF happens to be blocked fallopian tubes and the patient has had previous pregnancies, PGT may not indeed help increase the odds of success. 

  • Cost is a major concern

IVF can rather be very expensive and PGT is an additional expense. PGT is not a perfect method. If a person is looking to reduce the cost of an IVF cycle and prefers a frank discussion with the doctor about the pros and cons of genetic testing, it is better to consider not testing the embryos. This is not only cheaper but could mean moving onto a transfer and also hopefully pregnancy faster than if you had to wait for the results.

Conclusion

Choosing to perform genetic testing on embryos is indeed a highly personal decision that needs to be decided upon by the patient and the physician. 

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