Downregulation is a required process in IVF and can be done in reputed IVF clinics. It is processed in the pregnancy-related issues and is an essential component.
Patients do need to understand what down-regulation in IVF is all about. They also need to know the difference between a good IVF clinic and a bad IVF clinic. ivf specialist in Hyderabad, best fertility centre in Secunderabad do provide the required details of downregulation.
What does down-regulation mean and why it is needed?
When growing egg during an IVF cycle, one makes use of 2 processes – one is superovulation, while the other is down-regulation. Think of these as the 2 levers which do allow us to precisely control the egg production.
Superovulation, as the name suggests, does make use of hormones to help one to grow lots of eggs. These are natural hormones, and since one gives them in a higher dose, they do help to prevent the follicles from dying, so that one can grow many follicles in the IVF cycle.
Down-regulation does mean one needs to have another set of hormones, to prevent these follicles from rupturing on their own once they become mature.
While one stimulates one’s ovaries to grow lots of follicles ( which contain the eggs), it is also essential to switch off one’s pituitary at the same time, so that these follicles do not rupture on their own.
Down-regulation can either be done by using GnRH agonists, thus making use of what is called a long protocol or a short protocol, or by also using GnRH antagonists. Both these methods are equally effective, and the advantage of the GnRH antagonists is that one needs to take them for fewer days. Ivf specialist in Hyderabad, the best fertility center in Secunderabad is viable centers for downregulation.
These injections are given subcutaneously ( under the skin) and are easy to self-administer.
More about Downregulation….
Downregulation happens to be a process of reducing the sensitivity of a cell to a specific hormone or chemical. This is no doubt achieved by reducing the number of receptors on the surface of the cell. Receptors are how the cell can rather process and receive signals that come from outside of the cell. When an external substance is bound to a receptor, it does fit like a key in a lock and the receptor becomes full. Once this binding occurs, the substance can then also provide directions to the cell on what needs to be done (release a substance, etc.). The more cell the receptors are available, the greater the response to the external substance.
With down-regulation, the cell’s receptors are rather overexposed to an external substance (often a hormone) and this exposure does cause the body to decrease the number of receptors on the cell’s surface, which in turn has the effect of reducing the cell’s sensitivity. During fertility treatments, several medications are made use of for down-regulating various aspects of the female reproductive system.
During an in vitro fertilization (IVF) cycle, gonadotropin-releasing hormone (GnRH) agonists such as Lupron, Synarel, Suprecur, or Buserelin are made use of to prevent premature ovulation. Preventing premature ovulation is done in controlled ovarian stimulation (COS) protocols, especially in older women who do have a smaller ovarian reserve. It does ensure that ovulation occurs at the right time, with fully developed follicles, in preparation for an egg retrieval procedure.
This is done via a process of down-regulating both follicle-stimulating hormone (FSH) and luteinizing hormones (LH). FSH is required for follicle development and LH is essential for ovulation as well as androgen (male hormone) production. Ivf specialist in Hyderabad, best fertility centre in Secunderabad do have the required infrastructure for downregulation.
